Download e-book for iPad: Advances in Heterocycling Chemistry. Vol. 44 by Author Unknown

By Author Unknown

ISBN-10: 0080576311

ISBN-13: 9780080576312

ISBN-10: 0120206447

ISBN-13: 9780120206445

Show description

Read or Download Advances in Heterocycling Chemistry. Vol. 44 PDF

Best chemistry books

Get Coulson Richardson s Chemical Engineering PDF

Coulson and Richardson's vintage sequence presents the coed with an account of the basics of chemical engineering and constitutes the definitive paintings at the topic for lecturers and practitioners. This quantity covers the appliance of chemical engineering rules to the layout of chemical methods and kit.

Read e-book online Chemistry at Oxford: A History from 1600 to 2005 PDF

This interesting and certain background unearths the foremost impact of the Oxford Chemistry institution at the development of chemistry. It indicates how the character of the college, and participants inside of it, have formed the college and made nice achievements either in educating and examine. The ebook will entice these drawn to the heritage of technological know-how and schooling, the town of Oxford and chemistry normally.

New PDF release: Anomeric Effect. Origin and Consequences

Content material: The interplay among the ring-oxygen p-type lone pair and adjoining [sigma]-bonds in pyranose derivatives / Serge David -- The exo-anomeric influence / R. U. Lemieux, S. Koto, and D. Voisin -- Proton spin-lattice rest : a brand new, quantitative degree of aglycon-sugar interactions / J. M. Berry, L.

Read e-book online Chemistry of Nucleosides and Nucleotides: Volume 1 PDF

The current quantity is the 1st of a projected four-volume treatise. This quantity comprises the next chapters: "Synthesis and response of Pyrimidine Nucleosides," "Synthesis and homes of Purine Nucleosides and Nucleotides," and "Synthesis and houses of Oligonucleotides. " those 3 chapters have been chosen for inclusion in quantity I as the components have supplied the root and impetus for the initiation and improvement of the opposite parts of analysis, so as to be defined in next volumes.

Additional resources for Advances in Heterocycling Chemistry. Vol. 44

Example text

6dimethylpyridine Heterocycle 59 57 69 65 43 40 Sec. B] 6 35 ADVANCES IN THE CHICHIBABIN REACTION MeKNH (92) (9') SCHEME 36 methylamide to give a 40% yield of 6-methylamino-4-phenylpyrimidine (91) (Scheme 36) (83RTC367). The fact that only the a-adduct on C-6 (92) was observed and 91 was the only product obtained indicated that the SN(ANR0RC) mechanism was not involved in the Chichibabin reaction when an alkyl amide was the nucleophile, even though the SN(ANR0RC) mechanism is operative when 29 reacts with potassium amide (Section II,B,2).

Much information on the existence and position of the a-adducts has been accumulated by 'H- and 13C-NMR spectroscopy (83AHC(33)95). The 1,5-naphthyridine isomer (180) readily formed 2-aminodihydro-1,5naphthyridinide (186) with potassium amide in liquid ammonia at -40°C Sec. VLD] 53 ADVANCES IN THE CHICHIBABIN REACTION NAPHTHYRIDI NES N \ 1,5(14 Nm N N Nm N / ' E N N ~ 1,6- 1,7- 1,8- 2,6- 2,l- 683 (182) (1 83) (184) (1 8 5) leaving no trace of 180 (78JOC1673; 81JOC2134). When the temperature was allowed to rise to + lWC, isomerization occurred to give 4-aminodihydro-1,5naphthyridinide (187) (Scheme 66).

The yield of both isomers was 72‘;/, which is about the same as obtained with sodium amide. The predominance of 89 is due most likely to steric hindrance caused by the bulkiness of the aminating agent. The situation is similar to the amination with sodium amide of 3-substituted pyridines at atmospheric pressure, in which the bulk of the 3-substituent directs the amount of 2-amino-5-isomer formed (Section IV), except that in this case, it is the size of the aminating group that decides the ratio of isomers.

Download PDF sample

Advances in Heterocycling Chemistry. Vol. 44 by Author Unknown


by John
4.3

Rated 4.91 of 5 – based on 26 votes