By Andrew Eisen, Charles Krieger
Amyotrophic Lateral Sclerosis, in a different way referred to as Lou Gehrig's disorder, is among the many degenerative ailments of the getting older apprehensive method. this article well synthesizes the new explosion of analysis into this actual situation to build a close and complete review. Drs. Eisen and Krieger carry their examine services and huge scientific adventure to supply this sensible and thought-provoking account. Chapters disguise the epidemiology, molecular biology, and pathophysiology of ALS, in addition to matters pertinent to scientific evaluation and care.
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Extra info for Amyotrophic Lateral Sclerosis: A Synthesis of Research and Clinical Practice
However, there are other studies which have shown that ALS patients were exposed to a low selenium content (Hockberg et ai, 1997). Despite the fact that the association between metal toxicity and ALS is tenuous, there remains an attraction to a cause-effect relationship. A recent population-based case control study of the association of PD with exposure to iron, copper, manganese, mercury, zinc or lead reported a significant association with PD and occupational exposure to manganese and copper and a marginally significant association with lead.
Legs or chest wall), then ALS is more likely to be responsible for the overall disorder. On the other hand, if there is obvious cord compression, especially associated with myelomalacia of the cord on MRI, and unclear evidence of lower motor involvement caudal to the cervical cord, it is likely that the neurological deficit can be ascribed to the structural deformity. If there is doubt about the diagnosis of ALS, it is worth considering surgery even if the lesion does not explain the whole clinical picture.
Approaches that can be used are: 1. Cross-sectional prevalence studies, in which a sample of the general population is identified as to whether or not they have ALS and the risk factor of interest. This type of study provides relatively weak evidence with respect to causality and is not practical in ALS because of its low prevalence rate. 2. Cohort studies, which may be prospective or retrospective. In prospective studies a cohort would be defined having been exposed to a risk factor for a given period and followed for a fixed period to see if they develop ALS.
Amyotrophic Lateral Sclerosis: A Synthesis of Research and Clinical Practice by Andrew Eisen, Charles Krieger