John J. Langone (Eds.)'s Antibodies, Antigens, and Molecular Mimicry PDF

By John J. Langone (Eds.)

ISBN-10: 0121820793

ISBN-13: 9780121820794

The seriously acclaimed laboratory general, Methods in Enzymology, is among the so much hugely revered courses within the box of biochemistry. considering that 1955, each one quantity has been eagerly awaited, often consulted, and praised by means of researchers and reviewers alike. The sequence comprises a lot fabric nonetheless correct at the present time - really a vital ebook for researchers in all fields of existence sciences

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Extra info for Antibodies, Antigens, and Molecular Mimicry

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A. Miller, D. G. Maloney, R. Warnke, and R. Levy, N. Engl. J. Med. 306, 517 (1982). 16 IDIOTYPES, ANTI-IDIOTYPES, AND MOLECULAR MIMICRY [ll ness. The active immunotherapy of cancer patients with tumor-derived material includes various risk factors; above all, tumor-associated antigens (TAA) are often found to be poorly immunogenic. Therefore, alternative approaches should be explored to enhance tumor immunogenicity. A common explanation for the absence of antitumor immunity is that the immune system has been tolerized by the tumor antigen.

I. Freimuth, N. Treptow, S. Wentzel, W. L. Cleveland, and B. F. Erlanger, Proc. Natl. Acad. Sci. A. 79, 4810 (1982). 126j. y . Couraud, E. Escher, D. Regoli, V. Imhoff, B. Rossignol, and P. PradeUes, J. Biol. Chem. 2611, 9461 (1985). [1] IDIOTYPIC NETWORKS AND MOLECULAR MIMICRY 25 immunizing rabbits with antisubstance P antibodies. These anti-idiotypic antibodies inhibited the spasmogenic action of substance P on the guinea pig ileum. They specifically enhanced phospholipid turnover in rat parotid gland cells, a physiological function mediated through an activation of substance P receptors, in a similar way to substance P.

H. Ross, and H. Koprowski, Science 232, 100 (1986). S. Raychaudhuri, Y. -J. Chen, H. Iribe, H. Fuji, and H. Krhler, J. lmmunol. 139, 271 (1987). 101 S. Raychaudhuri, Y. Saeki, and H. Krhler, J. Immunol. 139, 3902 (1987). too [1] IDIOTYPIC NETWORKS AND MOLECULAR MIMICRY 19 of tumor-reactive cytotoxic T lymphocytes was found to be similar in mice immunized with Ab2 or with irradiated tumor cells when examined at the precursor level. However, only 2F10 induces protective immunity against the growth of L 1210/GZL tumor cells.

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Antibodies, Antigens, and Molecular Mimicry by John J. Langone (Eds.)


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